Agaricus Blazei / Royal Sun Agaricus

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Royal Sun Agaricus

Agaricus Blazei

Agaricus Blazei has well documented health effects.

As with other mushrooms, clinical efficacy is most often credited to complex polysaccharides, although clinical efficacy for cancer tumors has been documented to apply to non-polysaccharide components.

Research Summary.

  • There are five biologically relevant patents for use of Agaricus Blazei covering tumors, aids and immune competency improvement;
  • There are 75 articles that reference Agaricus Blazei in the NIH pubmed database.

See below for research details. These extracts are summarize the research data for Agaricus Blazei.

US Patents

Issued US Patents
Patent Link
Patent Title
Research Data
7,060,470 Isoflavone-.beta.-D-glucan produced by Agaricus blazei in the submerged liquid culture and method of producing same Cancer
6,897,046 Process of preparing biologically active substance Cancer & Liver
6,197,571 Protein polysaccharide 0041 Tumors
6,120,772 Oral drugs for treating AIDS patients Aids
6,093,694 Antitumor active substances Tumors/Cancer

NIH - Clinical Trial Data

Conclusions are provided for convenience. Please use the link to review article abstracts.

Clinical Trial Results
Study Link
Clinical Study Conclusions
Grinde 2006 Extracts from the mushroom Agaricus blazei Murill (AbM) are used extensively as a non-prescription remedy against cancer and infections, including hepatitis. We previously demonstrated a potent immunomodulating effect of a particular preparation on monocytes in vitro, and a protective effect on bacterial infections in mice. Here we report the effect on gene expression in peripheral blood cells from four chronic hepatitis C patients, using global (29 k) oligo-based, single channel microarrays. The viral load was slightly, but not significantly, decreased after 1 week of AbM treatment. The cytokine genes most strongly induced in vitro were not induced in vivo. The more notable changes in mRNA levels were related to genes involved in the G-protein coupled receptor signalling pathway, in cell cycling, and in transcriptional regulation. The results suggest that the beta-glucans of the extract, which presumably are responsible for cytokine induction, did not readily enter the blood, while other components, such as substances proposed to have anticancer effects, were active in the blood.
Ahn 1996 A mushroom extract, Agaricus blazei Murill Kyowa (ABMK), has been reported to possess antimutagenic and antitumor effects. Here, we investigate the beneficial effects of ABMK consumption on immunological status and qualities of life in cancer patients undergoing chemotherapy. One hundred cervical, ovarian, and endometrial cancer patients were treated either with carboplatin (300 mg / m(2)) plus VP16 (etoposide, 100 mg / m(2)) or with carboplatin (300 mg / m(2)) plus taxol (175 mg / m(2)) every 3 weeks for at least three cycles with or without oral consumption of ABMK. We observed that natural killer cell activity was significantly higher in ABMK-treated group (ANOVA, n = 39, P < 0.002) as compared with nontreated placebo group (n = 61). However, no significant difference in lymphokine-activated killer and monocyte activities was observed in a manner similar to the count of specific immune cell populations between ABMK-treated and nontreated groups. However, chemotherapy-associated side effects such as appetite, alopecia, emotional stability, and general weakness were all improved by ABMK treatment. Taken together, this suggests that ABMK treatment might be beneficial for gynecological cancer patients undergoing chemotherapy.


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